Figure 4.
Role of Rab GTPases in regulating GPCR trafficking. Rab5 plays a role in the formation, trafficking and fusion of endocytic vesicles with the early endosome. Rab5 interacts with the AT1R, which regulates Rab5 activity. Rab4 regulates the rapid recycling of vesicles containing GPCRs to the cell surface, whereas Rab11 regulates slow vesicular recycling. Rab7 plays a role in targeting GPCRs to the late endosome and lysosomes. Each of these Rab GTPases exhibits the capcity to interact with GPCR cargo proteins.