Figure 1.

Inhibitory effects of F 16618 on SFLLR-induced human washed platelet aggregation. Platelets were pre-incubated with various concentrations of F 16618 and stimulated with SFLLR 0.1– 50 µM for 5 min. (A) and (B) SFLLR-induced platelet aggregation in the presence of F 16618 (2.5, 5 and 7.5 µM). The percentage of the mean E_max is shown in (A), and the corresponding Schild plot is presented in (B), for the calculation of pA₂. (C) SFLLR (1.5 µM)-induced platelet aggregation was significantly inhibited by F 16618 (2, 3 and 4 µM). Each point represents the mean of duplicate tests, and the horizontal bar represents the mean value. (D) SFLLR (1.5 µM)-induced platelet aggregation expressed as the percentage of mean E_max used to calculate the IC₅₀ value. ***P < 0.001 versus untreated group.