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Inhibitory effects of F 16618 (5–20 µM) on human platelet aggregation in whole blood, induced by SFLLR 0.75 µM (n≥ 15) (A), SFLLR 1 µM (n≥ 19) (B), collagen 5 µg·mL−1 (n = 12) or PAR4-ap 100 µM (n = 11) (C). Aggregation is expressed as the area under the curve. (AUC) calculated after 6 min of activation. Each point represents the mean of duplicate tests, and the horizontal bar represents the mean value. **P < 0.01, ***P < 0.001 versus untreated group.
