Table 4.
Emetic compounds ranked by the intensity of the response in humans, dogs, ferrets and rats
| Human | Dog | Ferret | Rat |
|---|---|---|---|
| Cisplatin | Cisplatin | Cisplatin | Cisplatin |
| Ipecacuanha | Copper sulphate | Cyclophosphamide | Cyclophosphamide |
| Cyclophosphamide | Cyclophosphamide | Copper sulphate | Lithium chloride |
| Apomorphine | Apomorphine | Ipecacuanha | Apomorphine |
| Morphine | Morphine | Nicotine | |
| Ipecacuanha | Rolipram | Morphine | |
| Apomorphine | Rolipram | ||
| Lithium Chloride | Copper sulphate | ||
| Nicotine | CCK-8 | ||
| CCK-8 |
Note that maximal intensity was considered, regardless of the dose or mode of administration. Compounds are listed with those inducing the most intense emetic or pica response at the top and the least intense at the bottom.