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. Author manuscript; available in PMC: 2013 May 21.
Published in final edited form as: FEBS Lett. 2012 Mar 21;586(10):1409–1418. doi: 10.1016/j.febslet.2012.03.017

Figure 1. Schematic illustration of a SCF-type of E3 ubiquitin ligase complex.

Figure 1

The SCF (Skp1-Cullin 1-F-box) complex consists of four components: the invariable component Skp1, Rbx1 and Cullin1, and the interchangeable F-box protein that functions as a receptor for target proteins. FBW7 recognizes the targeted substrates, which are presented closely to the E2 enzyme to ensure consequent conjugation of ubiquitin. The addition of polyubiquitin targets proteins to the 26S-proteasome for degradation.