Table 1.
Reported Pirh2-binding partners.
| Protein | Function | Substrate |
|---|---|---|
| AIG1 | Activates NFAT signaling pathway [68] | n.d. |
| AR | Mediates androgen signaling in prostate development and differentiation [21,22] | no |
| ARF4 | Stimulates the ADP-ribosyltransferase activity [69] | n.d. |
| Axin | Acts as a tumor suppressor and a negative regulator of Wnt-signaling [45] | no |
| CaMKII | Serine/threonine-specific protein kinase that is regulated by calmodulin complex [70] | no |
| c-Myc | An oncogenic transcription factor that is activated by mitogenic signals [8] | yes |
| COP1 | A negative regulator of p53 [28] | n.d. |
| PolH | A DNA Polymerase involved in DNA repair by translesion synthesis [10,11] | yes |
| -COP | A subunit of COPI coatomer complex that is involved in Golgi-trafficking [23] | yes |
| HDAC1 | A histone deacetyltransferase that is responsible for the deacetylation of histone [22] | yes |
| K8/18 | A major components of intermediate filaments in single layer epithelial cells [71] | no |
| Mdm2 | A major negative regulator of p53 [28] | n.d. |
| Mdmx | A enzymatically inactive component of Mdm2 complex [28] | n.d. |
| MV P | Contributes to innate immune evasion [72] | no |
| PCV2 ORF3 | Induces apoptosis and regulates p53 ubiquitination [73,74] | n.d. |
| p27 | Inhibits G1-S transition [9] | yes |
| p53 | A tumor suppressor [13,20] | yes |
| p73 | A member of p53-superfamily proteins [12,63] | yes |
| PLAGL2 | Acts as a transcription factor and suppresses cellular differentiation [25] | n.d. |
| SCYL1-BP1 | A member of the Golgin family which is involved in the secretary pathway [26,27] | yes |
| SR | A docking protein that is involved in targeting secretary protein to ER [75] | yes |
| Tip60 | A histone acetyltransferase that has a role in the DNA damage response [24] | n.d. |
AIG1, androgen induced gene 1; AR, androgen receptor; ARF4, ADP-ribosylation factor 4; CaMKII, calmodulin kinase II; COP1, constitutive photomorphogenesis protein1; PolH, DNA polymerase eta; HDAC1, histone deacetylase 1; Mdm2, murine double minute 2; PCV2 ORF3, porcine circovirus type 2 open reading frame 3; PLAGL2, pleomorphic adenoma gene like 2; SCYL1-BP1, SCY1-like 1 binding protein 1; SR, signal recognition particle receptor ; Tip60, tat-interactive protein of 60 kDa.