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. Author manuscript; available in PMC: 2013 Jun 19.
Published in final edited form as: Vaccine. 2012 Jun 19;30(29):4316–4322. doi: 10.1016/j.vaccine.2012.01.034

Figure 3. Correlation of IL-17A response and survival in a surface phagocytosis assay.

Figure 3

Correlation of median IL-17A responses stimulated by capsule-switch isogenic pneumococcal whole cell antigens in WCV-immunized splenocytes with relative survival from surface phagocytosis (normalized to survival by the serotype 14 strain, as measured in [9]). IL-17A responses correlate significantly and inversely with survival from neutrophil-mediated surface phagocytosis (Spearman ρ = −0.6545; p = 0.03). The isogenic capsule-switch variants eliciting the highest IL-17A demonstrate the lowest survival index in an in vitro assay of surface phagocytosis.