Table 4.
Expression of apoptosis-related genes, DNA repair, and histone family of genes in DBA BM progenitors
| Affymetrix identification | Gene symbol | LocusLink | Fold change
|
||
|---|---|---|---|---|---|
| P | E | M | |||
| 209295_at | TNFRSF10B | 8795 | — | 10.1 | 3.09 |
| 204780_s | TNFRSF6 | 355 | — | 3.03 | — |
| 209508_x_at | CFLAR | 8837 | — | −3.77 | — |
| 211833_s | BAX | 581 | 3.49 | 2.71 | 2.43 |
| 212969_x_at | MTA2 | 256364 | — | −12.8 | — |
| 208368_s | BRCA2 | 675 | −2.59 | −4.85 | — |
| 203742_s | TDG | 6996 | — | 3.48 | — |
| 213344_s_at | H2AX | 3014 | — | −5.04 | — |
| 208694_at | DNA-PK | 5591 | −2.24 | — | — |
| 203409_at | DDB2 | 1643 | — | 3.73 | 2.08 |
| 214469_at | HIST1H2AE | 3012 | — | −5.49 | — |
| 222067_x_at | HIST1H2BD | 3017 | — | −5.13 | — |
| 208490_x_at | HIST1H2BF | 8343 | — | −6.24 | — |
| 208546_x_at | HIST1H2BH | 8345 | — | −3.98 | — |
| 209398_at | HIST1H1C | 3006 | — | −17.1 | — |
| 208579_x_at | H2BFS | 54145 | — | −7.76 | — |
| 213826_s_at | H3F3A | 3020 | — | −5.85 | — |
| 203582_s_at | RAB4A | 5867 | −2.12 | −5.97 | −2.21 |
| 221960_s_at | RAB2 | 5862 | — | −5.34 | — |
| 205037_at | RABL4 | 11020 | — | −5.09 | — |
| 219622_at | RAB20 | 55647 | — | — | 2.34 |
| 203885_at | RAB21 | 23011 | 2.11 | — | — |
| 212099_at | ARHG | 388 | — | −6.54 | — |
| 203132_at | RB1 | 5925 | −2.3 | — | – |
| 200658_s_at | PHB | 5245 | — | — | −2.48 |
| 202377_at | LEPR | 3953 | 3.07 | — | — |
| 209894_at | LEPR | 3953 | — | — | 4.49 |
A positive value indicates upregulation, and a negative value indicates downregulation in cells from DBA patients. —, not significantly changed.
Abbreviations: DBA, Diamond-Blackfan anemia; E, bone marrow erythroid progenitor; M, myeloid progenitor; P, multipotential progenitor.