FIG 3 .

Weight loss and lethality in mice infected with the D131E and S186P CA/09 mutants. Weight loss (A) and mortality (B) were monitored for 14 days after intranasal inoculation with 10⁵ TCID₅₀ of biological and recombinant CA/09 wt and mutant viruses in groups of five mice. Mice were euthanized if they lost at least 25% of their original body weight. In panel A, the numbers beside each line represent the number of mice that survived per group of five mice. Numbers in parentheses represent results from multiple groups.