FIG 3 .
Onset of BBB disruption is delayed in C.SJL-Msq1SJL mice. Mice were either mock infected or MAV-1 infected at 104 PFU and assayed for BBB disruption using Evans blue dye at 3, 4, and 5 dpi. (A) Viral loads of individual infected mouse brains were measured by capture ELISA. Each symbol represents the mean of three measurements per homogenate. (B) The amount of Evans blue dye in infected mouse brains is represented as a ratio to the amount of dye found in mock-infected brains for each individual strain. Each symbol represents the average of duplicate measurements for an individual mouse; numbers of mice in each group are indicated. Means and SDs are indicated. Statistical significance was calculated by a two-tailed Mann-Whitney test.