TABLE 3.

AIRWAY FUNCTION BY VEGF SNPs FOR ADULTS AND CHILDREN WITH ASTHMA

		Z Scores of Adjusted FEV1/FVC Ratio*
		Manchester Adults				Croatian Asthma Study (All Children)				Croatian Asthma Study (Children >10 yr)
VEGF-A SNPs		n	Mean	95% CI	P	n	Mean	95% CI	P	n	Mean	95% CI	P
rs3025028	CC	130	0.22	0.05 to 0.39		68	0.23	0.00 to 0.45		30	0.18	−0.15 to 0.51
	CG	275	0.02	−0.09 to 0.14		202	0.01	−0.12 to 0.14		123	−0.22	−0.38 to −0.06
	GG	162	−0.05	−0.20 to 0.10	0.02	130	−0.07	−0.24 to 0.10	0.05	68	−0.34	−0.56 to −0.12	0.018
rs10434	AA	139	0.23	0.06 to 0.39		65	0.24	0.01 to 0.48		29	0.16	−0.18 to 0.49
	AG	299	−0.04	−0.15 to 0.07		203	0.00	−0.13 to 0.14		123	−0.23	−0.39 to −0.07
	GG	153	−0.03	−0.18 to 0.13	0.03	123	−0.09	−0.26 to 0.08	0.03	64	−0.35	−0.58 to −0.13	0.024

Definition of abbreviations: CI = confidence interval; SNP = single-nucleotide polymorphism; VEGF = vascular endothelial growth factor.

^*Adjusted for Manchester adults: age, sex, height, and cigarette smoking pack-years. Adjusted for Croatia Asthma Study: height, age, and sex. P value is for analysis of variance model.