Table 2.
Readouts of Tau toxicity in Drosophila.
| Organ/Tissue/Cells | Phenotypes | Promoters/Drivers |
|---|---|---|
| Eye | Roughness | GMR |
| Photoreceptor cell viability | Gl | |
| Sev | ||
|
| ||
| Notum | Loss of bristles | Eq |
|
| ||
| Nervous system | Lethality | Elav |
| Shortened lifespan | Appl | |
| Brain vacuolisation | Repo | |
| TUNEL positive cells | Gl | |
| Activated caspase3 positive cells | C472 | |
| Loss of olfactory Learning and memory | C772 | |
|
| ||
| Motor neurons | Axonal transport defects | D42 |
| Locomotor deficits | OK6 | |
| “juvenile” phenotype: loss of wing | Elav | |
| expansion and cuticle tanning | Burs12 | |
| Appl | ||