Table 2.
Differentially expressed genes involved in apoptosis detected by significant enrichment analysis of GO terms using the R language software package.
| Genes | GenBank accession | Fold change | Gene description |
|---|---|---|---|
| PDCD7 | NM_005707 | −2.20 | Programmed cell death 7 |
| RRAGA | NM_006570 | 2.03 | Ras-related GTP binding A |
| DAPK3 | NM_001348 | 2.04 | Death-associated protein kinase 3 |
| PUF60 | NM_014281 | −2.00 | Poly-U binding splicing factor 60kda isoform c |
| FOXO3 | NM_001455 | 2.16 | Forkhead box O3A |
| ARHGEF18 | NM_015318 | 2.20 | Rho/Rac guanine nucleotide exchange factor 18 |
| BBC3 | NM_014417 | −2.18 | BCL2 binding component 3 isoform 1 |
| GSN | NM_198252 | 5.02 | Gelsolin isoform c |
| LGALS1 | NM_033101 | 2.58 | Galectin-1 |
| NFKB1 | NM_003998 | −3.33 | Nuclear factor kappa-B, subunit 1 isoform 1 |
| SH3GLB1 | NM_016009 | 2.82 | SH3-containing protein SH3GLB1 |
| POLR2G | NM_002696 | 2.02 | DNA directed RNA polymerase II polypeptide G |
| DDIT4 | NM_019058 | −2.23 | Homo sapiens DNA-damage-inducible transcript 4 |
| STEAP3 | NM_182915 | −2.52 | Dudulin 2 isoform a |
| DRAM1 | NM_018370 | 2.29 | DNA-damage regulated autophagy modulator 1 |
| RNF130 | NM_018434 | 2.07 | Ring finger protein 130 precursor |
| AVEN | NM_020371 | −2.62 | Cell death regulator Aven |
| TRIB3 | NM_021158 | −2.19 | Tribbles 3 |
| BAX | NM_138764 | 2.06 | BCL2-associated X protein isoform beta |
| BID | NM_197966 | −2.76 | BH3 interacting domain death agonist isoform 1 |
| PERP | NM_022121 | 9.42 | PERP, TP53 apoptosis effector |
| SPTAN1 | NM_003127 | 2.63 | Spectrin, alpha, nonerythrocytic 1 |
| BUB1B | NM_001211 | −2.20 | Budding uninhibited by benzimidazoles 1 beta |
| VDAC1 | NM_003374 | −2.37 | Voltage-dependent anion channel 1 |
| BCL2L12 | NM_138639 | 2.19 | BCL2-like 12 isoform 1 |
| CUL1 | NM_003592 | −2.08 | Cullin 1 |
| YARS | NM_001040436 | −2.30 | Tyrosyl-TRNA synthetase |
| TNFSF9 | NM_003811 | 2.38 | Tumor necrosis factor (ligand) superfamily |
| IER3 | NM_003897 | 2.17 | Immediate early response 3 |
| ARHGEF2 | NM_004723 | −2.10 | Rho/Rac guanine nucleotide exchange factor 2 |
| TP53INP1 | NM_033285 | 3.03 | Tumor protein p53 inducible nuclear protein 1 |
| ITM2B | NM_021999 | 2.32 | Integral membrane protein 2B |
| LITAF | NM_004862 | 2.25 | Lipopolysaccharide-induced TNF-alpha factor |
| ESPL1 | NM_012291 | −2.11 | Separase |
−: indicate downregulation.