Table 3.

Differences of the Barkley Side Effects Measured Between Baseline and Visit 3, as Well as Between Baseline and End Point

	n=439				n=439
	Visit 3–Baseline		Group difference		Endpoint–Baseline		Group difference
	Baseline (n=521) Mean±SD	Visit 3 (n=472) Mean±SD	t value	p value	Baseline (n=521) Mean±SD	Endpoint (n=439) Mean±SD	t value	p value
Barkley side effects
Poor appetite	2.74±2.81	2.75±2.65	0.05	0.961	2.74±2.81	2.67±2.66	−0.49	0.623
Trouble sleeping	1.86±2.49	1.72±2.36	−1.22	0.225	1.86±2.49	1.41±2.16c	−3.83	0.001
Stomach aches	0.54±1.50	0.38±1.27a	−2.24	0.026	0.54±1.50	0.23±0.94d	−5.01	<0.001
Headaches	0.82±1.58	0.41±1.10d	−6.02	<0.001	0.82±1.58	0.28±0.99d	−7.32	<0.001
Nightmares	0.76±1.55	0.42±1.15d	−4.74	<0.001	0.76±1.55	0.30±1.01d	−5.74	<0.001
Daydreams	1.40±2.18	0.64±1.40d	−7.92	<0.001	1.40±2.18	0.48±1.25d	−9.67	<0.001
Reduced communication	0.99±1.85	0.66±1.33d	−3.59	<0.001	0.99±1.85	0.50±1.21d	−5.03	<0.001
Uninterested in others	1.28±2.17	0.72±1.34d	−5.40	<0.001	1.28±2.17	0.52±1.23d	−6.74	<0.001
Shock	0.62±1.46	0.34±1.10d	−4.17	<0.001	0.62±1.46	0.28±0.97d	−5.27	<0.001
Dry mouth	1.56±2.28	1.10±1.94d	−4.59	<0.001	1.56±2.28	0.73±1.60d	−8.00	<0.001
Sentimental	1.31±2.17	0.82±1.62d	−4.98	<0.001	1.31±2.17	0.60±1.42d	−6.99	<0.001
Anxiety	1.39±2.23	0.84±1.67d	−5.66	<0.001	1.39±2.23	0.60±1.47d	−7.35	<0.001
Biting fingernails	2.08±3.09	1.17±2.27d	−8.76	<0.001	2.08±3.09	0.90±1.97d	−10.04	<0.001
Unusually happy	1.05±2.11	0.57±1.47d	−5.23	<0.001	1.05±2.11	0.33±1.14d	−8.18	<0.001
Drowsiness	0.77±1.77	0.52±1.37b	−2.92	0.004	0.77±1.77	0.36±1.25d	−4.73	<0.001
Tics/nervous movement	0.45±1.40	0.29±1.01b	−2.66	0.008	0.45±1.40	0.25±1.04b	−2.96	0.003

^ap<0.05; ^bp<0.01; ^cp=0.001; ^dp<0.001 by the paired t test

SD=standard deviation.