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. Author manuscript; available in PMC: 2012 Jun 12.
Published in final edited form as: Eur J Immunol. 2010 Dec;40(12):3347–3357. doi: 10.1002/eji.201041037

Figure 2. Tumor and host derived IL-1β regulates size of splenic Ly6Cneg MDSC pool.

Figure 2

Cells were identified as indicated in Figure 1B and Supplemental Figure 2A. (A) The total numbers of PMN-MDSC isolated from BALB/c mice bearing 4T1 (tumor diameter: 7 mm) treated with or without rIL-1β. (B) The total numbers of PMN-MDSC isolated from BALB/c and IL-1Ra−/− mice bearing 4T1. (C) The total numbers of PMN-MDSC isolated from BALB/c mice bearing 4T1/IL-1β tumor cells (tumor diameter: 7 mm) treated with or without rIL-1Ra. (D) The total numbers of PMN-MDSC isolated from BALB/c and IL-1β−/− mice bearing 4T1/IL-1β tumor cells. Error bars show SD. *p<0.05, calculated two-sided Student’s t-test.