Figure 1.

Choroidal neovascularization (CNV) associated with age-related macular degeneration treated with ranibizumab.

Notes: (Top left) Left eye of an 81-year-old man with CNV associated with age-related macular degeneration. Initial visual acuity in the left eye was 0.2 in a Landolt chart (0.70 in logarithm of the minimal angle of resolution) and refractive error was −1.75 Diopter. (Top middle) Fluorescein angiography shows a minimally classic CNV. (Top right) Indocyanine green angiography shows no polypoidal lesions. (Middle) A horizontal section through the fovea obtained by optical coherence tomography with the enhanced-depth imaging technique before the treatment. Multiple cystoid spaces are seen. Central retinal thickness was 529 μm, and central choroidal thickness was 105 μm. (Bottom) A horizontal section through the fovea after three monthly injections of ranibizumab at the loading phase. Intraretinal fluid was absorbed completely (central retinal thickness, 157 μm), and visual acuity improved to 0.3 in a Landolt chart (0.52 in logarithm of the minimal angle of resolution). The choroidal structure shows no changes (central choroidal thickness, 101 μm). At 9 months, the central choroidal thickness was still 103 μm.

Abbreviation: CSI, chorioscleral interface.