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BACE1 enzymatic activity in the cortical and hippocampal tissues from the brains of transgenic and WT mice. (A) Changes in BACE1 activity of all four genotype groups (*P < 0.05; **P < 0.005). (B) Differences across the ages (**P < 0.005). (C) Difference in BACE1 activity in the AβPP and MCAT/AβPP mice at the three ages (**P < 0.005).
