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8-OHdG quantification, using high pressure liquid chromatography (HPLC) analysis of the cortical and hippocampal tissues from the brains of transgenic and WT mice. (A) Changes in the levels of 8-OHdG in all four genotype groups (*P < 0.05; **P < 0.005). (B) Differences across the ages (*P < 0.05). (C) Levels of 8-OHdG in the AβPP and MCAT/AβPP mice at the three ages (*P < 0.05; **P < 0.01).
