Table 3.

Replication of selected SNPs in a cohort of West Africans and meta-analysis results in the discovery and replication data sets

Chromosome	SNP	Genes	Africa America Diabetes Mellitus study (n=486)			Howard University Family Study (n=837)			Meta-analysis (n=1323)
			CAa (CAF)b	P-value	Beta (SE)	CAa (CAF)b	P-value	Beta	P-value	Beta (SE)	Dir.	P(Het)*	I2	P-value**
1	rs16827466c	CRPP1	T (0.48)	0.46	0.05 (0.07)	T (0.19)	4.3 × 10−11	0.47 (0.07)	9.6 × 10−08	0.27 (0.05)	++	4.3 × 10−05	94	1.0 × 10−5
1	rs7531832	CRPP1	G (0.22)	0.004	0.27 (0.09)	G (0.17)	5.9 × 10−11	0.50 (0.08)	2.8 × 10−12	−0.40 (0.06)	–	5.9 × 10−02	72.1	0.37
1	rs726640	CRPP1	A (0.21)	0.0008	0.34 (0.10)	A (0.17)	5.0 × 10−11	0.50 (0.08)	1.8 × 10−13	0.44 (0.06)	++	2.1 × 10−01	36.3	0.47
1	rs16842525	CRPP1	C (0.20)	0.002	0.31 (0.10)	C (0.19)	6.8 × 10−10	0.44 (0.07)	5.9 × 10−12	−0.40 (0.06)		2.9 × 10−01	11.7	0.86
1	rs1341666	CRPP1	G (0.21)	0.002	0.31 (0.10)	G (0.19)	6.8 × 10−10	0.44 (0.07)	7.6 × 10−12	-0.40 (0.06)	–	2.6 × 10−01	20.9	0.72
1	rs12239267	CRPP1	T (0.21)	0.005	0.28 (0.10)	T (0.18)	2.4 × 10−09	0.44 (0.07)	6.0 × 10−11	0.39 (0.06)	++	2.2 × 10−01	34.9	0.59
1	rs6667499	CRPP1	A (0.21)	0.002	0.31 (0.10)	A (0.21)	9.4 × 10−10	0.42 (0.07)	7.0 × 10−12	0.38 (0.06)	++	3.5 × 10−01	0	1.0
1	rs3093058	CRP	A (0.21)	0.003	0.29 (0.10)	A (0.21)	7.6 × 10−10	0.43 (0.07)	1.0 × 10−11	0.39 (0.06)	++	2.7 × 10−01	19.2	1.0
1	rs9628671	CRP	T (0.23)	0.006	0.26 (0.10)	T (0.21)	1.3 × 10−09	0.42 (0.07)	4.5 × 10−11	0.38 (0.06)	++	1.9 × 10−01	42.5	0.73
1	rs16827462	CRPP1	A (0.22)	0.001	0.33 (0.10)	A (0.19)	9.8 × 10−08	0.40 (0.07)	4.2 × 10−10	0.37 (0.06)	++	5.8 × 10−01	0	0.60

^aCA, coded allele.

^bCAF, coded allele frequency.

^crs16827466 has been merged into rs10494326.

*P-value for heterogeneity test.

**P-value for the test of allele frequency difference between WA and AA.