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Role of ABCG2 and ABCB1 knockdown in enhancing cytotoxic effects of anti-cancer drugs at 1 nM
| siRNA | % enhancement of chemosensitivity | ||
|---|---|---|---|
|
|
|||
| Doxorubicin | Paclitaxel | Cisplatin | |
| ABCG2+ABCB1 1 nM (each) | 43% | 49% | 50% |
| ABCG2 1 nM | 14% | 17% | 16% |
| ABCB1 1 nM | 18% | 26% | 10% |
Abbreviation: siRNA, small interfering RNA.
