Table 2.
Properties of mPEG-P(LA-co-GA)2 nanoparticles
| Copolymers | CAC (10−3 g L−1) | Rh (nm) | DLC (wt %) | DLE (wt %) | IC50 (10−3 g L−1) | ||
|---|---|---|---|---|---|---|---|
|
| |||||||
| 24 h | 48 h | 72 h | |||||
| mPEG113-P(LA4-co-GA9)2 | 65.3 ± 1.0 | 88 ± 2.5 | 6.96 ± 0.2 | 41.76 ± 0.6 | 3.74 | 2.02 | 1.79 |
| mPEG113-P(LA12-co-GA9)2 | 5.68 ± 0.2 | 78 ± 2.1 | 7.35 ± 0.3 | 44.10 ± 0.7 | 3.13 | 1.91 | 1.83 |
| mPEG113-P(LA24-co-GA8)2 | 3.24 ± 0.1 | 144 ± 1.4 | 8.50 ± 0.2 | 51.00 ± 0.5 | 2.81 | 1.96 | 1.91 |
| mPEG113-P(LA45-co-GA15)2 | 1.52 ± 0.1 | 32 ± 3.2 | 10.34 ± 0.2 | 62.04 ± 0.4 | 4.08 | 1.94 | 1.73 |
Abbreviations: mPEG, monomethoxy poly(ethylene glycol); P(LA-co-GA), poly(L-lactide-co-glycolide); CAC, critical aggregation concentration; Rh, hydrodynamic radius; DLC, drug loading content; DLE, drug loading efficiency; IC50, half maximal inhibitory concentration.