Figure 4. A COX-2 inhibitor does not occlude the effect of stress on DSI.
(A and B) Bath-application of the COX-2 inhibitor, meloxicam (Mel), 30 μM, prolonged DSI (2-s step) duration in control (A, n=7) and stressed cells (B, n=8). Representative traces from a control (A) and a stressed (B) cell are shown above. Cal. bar: 20s, 200pA. (C) Group data τd; each circle represents one cell. Meloxicam enhances τd in control, **p < 0.01, and stressed cells *p < 0.05; Stress BLτd is greater than control BLτd; #p < 0.05. (D) Meloxicam increased Δ DSI integral similarly in control and stressed cells. Each circle represents one cell.
