Table 2.
Selected characteristics of co-medication subpopulation in the MMTP (128 patients) according to the presence or absence of methadone-drug interactions (MDIs)
| No interaction (n = 43) | Drug interaction (n = 85) | df | P-value* | |
|---|---|---|---|---|
| Mean age, (SD) | 40.7 (6.8) | 39.0 (7.4) | 127 | 0.20 |
| Male, n (%) | 36 (83.7) | 75 (88.2) | 1 | 0.47 |
| Mean body mass index, kg/m2 (SD) | 23.6 (3.3) | 24.4 (3.9) | 125 | 0.24 |
| Education, n (%) | ||||
| Less than high school | 26 (60.5) | 47 (55.3) | 1 | 0.58 |
| High school or above | 17 (39.5) | 38 (44.7) | ||
| Marital status, n (%) | ||||
| Married or living with partner | 13 (30.2) | 27 (32.1) | 2 | 0.69 |
| Never married | 24 (55.8) | 41 (48.8) | ||
| Divorced/widowed | 6 (14.0) | 16 (19.1) | ||
| Employment, n (%) | ||||
| Employed | 30 (69.8) | 55 (64.7) | 1 | 0.57 |
| Other | 13 (30.2) | 30 (35.3) | ||
| Current illicit drug use, n (%) | ||||
| Heroin | 22 (51.2) | 30 (35.3) | 1 | 0.08 |
| Amphetamine(s) | 1 (2.3) | 3 (3.5) | 1 | 0.99 |
| Benzodiazepine(s) | 7 (16.3) | 14 (16.5) | 1 | 0.98 |
| Heroin use years, (SD) | 9.5 (6.3) | 7.6 (5.1) | 119 | 0.11 |
| Drug use in the past, n (%) | ||||
| Heroin | 43 (100) | 85 (100) | 1 | -- |
| Amphetamine(s) | 26 (60.5) | 56 (65.9) | 1 | 0.55 |
| MDMA | 0 (0.0) | 8 (9.4) | 1 | 0.05 |
| Ketamine | 1 (2.3) | 10 (11.8) | 1 | 0.10 |
| Other substance use, n (%) | ||||
| Cigarettes | 33 (83.7) | 73 (85.9) | 1 | 0.75 |
| Alcohol | 13 (30.2) | 30 (35.3) | 1 | 0.57 |
| Betel quid | 9 (20.9) | 28 (32.9) | 1 | 0.16 |
| HCV coinfection, n (%) | 42 (97.7) | 79 (92.9) | 1 | 0.42 |
| HBV coinfection (HBsAg-positive), n (%) | 9 (20.9) | 18 (21.2) | 1 | 0.97 |
| Current methadone dose, mg (SD) | 53.9 (25.7) | 53.0 (29.7) | 127 | 0.86 |
| MMTP participation period, months (SD) | 17.7 (12.5) | 22.8 (13.8) | 126 | 0.04* |
*: statistical significance set at p < 0.05; Comparisons performed by the Mann-Whitney U test, Chi-square test or Fisher's exact test when appropriate