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. 2012 Jun 11;197(6):789–800. doi: 10.1083/jcb.201110049

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© 2012 Liem et al.

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Figure 5. — Neural patterning in Ift144^twt Ift122^sopb double mutants resembles that in Ift144^dmhd. (A) Based on expression of HB9-GFP, Ift144^twt Ift122^sopb double-mutant embryos lack motor neurons in the anterior spinal cord (arrow) but retain them in caudal regions. The double mutants are exencephalic and have laterality defects, similar to Ift144^dmhd. WT, wild type. (B) Cross-sections through Ift144^twt, Ift122^sopb, and Ift144^twt Ift122^sopb double-mutant embryos at E10.5, marked by the expression of HB9-GFP and FoxA2. Ift144^twt/Ift122^sopb double mutants lack FoxA2+ floor plate cells at all levels, lack cervical motor neurons, and show dorsally expanded motor neurons at lumbar levels, like Ift144^dmhd. Bars: (A) 1 mm; (B) 200 µm.