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. 2012 Jun 12;7(6):e38568. doi: 10.1371/journal.pone.0038568

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Jumlongras et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Homologous genomic pair-wise alignments between human and mouse (Human-Mouse) and Fugu and mouse (Fugu-Mouse) were generated using BLASTZ. Genomic sequence of 159 kb surrounding the mouse Bmp4 gene (76 kb 5′ of the Bmp4 transcriptional start site and 83 kb 3′ of it) was used as reference. The Bmp4 gene (green) consists of 4 exons as (triangles denote IA, IB, II, III and IV) with the 2.4 kb proximal Bmp4IA promoter region (brown) upstream of exon IA. Transcriptional direction is designated by the exon triangles and genomic positions upstream and downstream of the transcriptional start site (position 0) are denoted in (−) and (+) numbers, respectively. Human-Mouse and Fugu-Mouse homologies of >75% identity over 50 bp regions are shown as blocks of sequence conservation. CONS1, CONS2, CONS3 and CONS4 (pink) encompass clusters of conservation blocks. Note: Two blocks of Fugu-Mouse sequence conservation are located 46 kb upstream and 80 kb downstream of the Bmp4 transcription start site, respectively. The 46 kb upstream Fugu-Mouse conservation block is embedded within the CONS3 region.