Table 3. Multivariate analysis of protein analyte data for COPD subjects.

Lung Function Parameter	Spearman Correlation	Adjusted R Squared	Analytes
FEV1%predicted	0.48	0.03	HB-EGF, EN-RAGE, MIP-1β
FEV1/FVC ratio	0.47	0.14	NGAL, HB-EGF, GST-α, MIP-1β
DLCO %predicted	0.43	0.21	HB-EBF, MCP-4, Fibrinogen, sRAGE, Sortilin

Spearman correlation and adjusted R squared values were computed using test set samples, in a 5-fold nested cross-validation scheme, averaged over 10 random seeds. R squared values were adjusted for the number of predictor terms in the model.