Table 4. Univariate regression analysis of protein analytes versus lung function parameters in COPD subjects with and without metabolic syndrome.

	With Metabolic Syndrome (n  = 55)		Without Metabolic Syndrome (n  = 47)
Lung Function Parameter/Analyte	Spearman Correlation	p (FDR)	Spearman Correlation	p (FDR)	Interaction p
FEV1/FVC ratio
MPO	−0.15	0.96	−0.61	0.023	0.09
NGAL	−0.35	0.25	−0.54	0.023	0.65
DLCO % predicted
Fibrinogen	−0.25	0.47	−0.52	0.005	0.08
HB-EGF	−0.44	0.13	−0.45	0.027	0.55
MCP-4	−0.52	0.03	−0.28	0.342	0.29

Significance (p values) and effect sizes (spearman correlation) are listed for biomarker associations with lung function parameters. Interaction p values indicate significance of differences in biomarker associations with lung function parameters, between metabolic syndrome and non- metabolic syndrome groups.