Table 2. Wee1 expression correlates with clinical parameters- and markers of tumor progression.

Clinical parameter	No. Analyzed	Expression	Low	High	p-value †
Mean tumor depth	105		1.99 mm	3.90 mm	0.001
T-stage
T1 (0–1 mm)	27		22 (81%)	5 (19%)	0.004
T2 (1.01–2.0 mm)	34		21 (62%)	13 (38%)
T3 (2.01–4 mm)	18		7 (39%)	11 (61%)
T4 (>4 mm)	26		10 (38%)	16 (62%)
Ulceration	100	No	46 (46%)	22 (22%)	0.005
		Yes	12 (12%)	20 (20%)
Marker *
Cyclin A	99	Low	39 (39%)	12 (12%)	<0.0001
		High	19 (19%)	29 (29%)
Ki67	99	Low	46 (46%)	17 (17%)	<0.0001
		High	12 (12%)	24 (24%)
Cyclin D3	99	Low	48 (48%)	21 (21%)	0.001
		High	10 (10%)	20 (20%)
p21Cip1/WAF1	71	Low	30 (42%)	9 (13%)	0.003
		High	13 (18%)	19 (27%)
p53	67	Low	38 (57%)	20 (30%)	0.025
		High	2 (3%)	7 (16%)

^*Low expression of Cyclin A [11], Ki67 [11], Cyclin D3 [12], p21 [13] and p53 [14]; defined as immunoreactivity in <5% of the tumor cells. Wee1 expression in <10% of tumor cells is defined as low.

^†Statistical significances determined by Chi-square tests.