Table 2. Univariate and Multivariate logistic regression analysis of factors independently associated with treatment default for tuberculosis patients from Amazonas State, Brazil 2005–2010.
| CASES | CONTROLS | Univariate analysis | Multivariate analysis | ||||
| Crude OR (95% CI) | Adjusted OR (95% CI) | ||||||
| DEFAULTERS (%) | CURED (%) | p | p | ||||
| Sex | Male | 1059 (16.00) | 5657 (84.00) | 1.45(1.29–1.62) | 0.00000 | 1.12(0.97–1.30) | 0.11275 |
| Female | 525 (11.00) | 4071 (89.00) | 1.00 | ||||
| Treated living area | Yes | 46 (14.00) | 272 (86.00) | 1.04 | |||
| No | 1538 (14.00) | 9456 (86.00) | 1.00 | 0.80946 | |||
| Living in Manaus | Yes | 1195 (15.00) | 6659 (85.00) | ||||
| No | 389 (11.00) | 3069 (89.00) | 1.42 | 0.00000 | 0.92(0.76–1.10) | 0.35715 | |
| Living area | Urban | 1426 (14.00) | 8606 (86.00) | 1.33 | |||
| Rural | 137 (12.00) | 994 (88.00) | 1.10 | ||||
| Peri-urban | 5 (11.00) | 40 (89.00) | 1.00 | 0.13259 | |||
| Treatment type | Previous default | 218 (47.00) | 249 (53.00) | 5.99 | 0.00000 | 3.20(2.25–4.57) | 0.00000 |
| Relapse | 61 (12.00) | 427 (88.00) | 0.98 | 0.68(0.43–1.08) | 0.10140 | ||
| Transferred | 71 (11.00) | 604 (89.00) | 0.80 | 0.74(0.48–1.13) | 0.16792 | ||
| New case | 1233 (13.00) | 8440 (87.00) | 1.00 | ||||
| Clinical Form | Mixed | 45 (18.00) | 210 (82.00) | 1.27 | 0.00014 | 1.21(0.82–1.78) | 0.33584 |
| Extrapulmonary | 163 (11.00) | 1357 (89.00) | 0.71 | 0.91(0.67–1.25) | 0.56372 | ||
| Pulmonary | 1376 (14.00) | 8161 (86.00) | 1.00 | ||||
| AFB sputum smear | Negative | 736 (15.00) | 4158 (85.00) | 1.17 | 0.02087 | 1.23(0.98–1.54) | 0.07404 |
| Not done | 140 (13.00) | 902 (87.00) | 1.02 | 0.90(0.67–1.21) | 0.47094 | ||
| Positive | 708 (13.00) | 4668 (87.00) | 1.00 | 1.00 | |||
| HIV | Positive | 154 (21.00) | 568 (79.00) | 2.80 | 0.00000 | 1.62(1.38–1.89) | 0.00000 |
| No results | 174 (20.00) | 686 (80.00) | 2.62 | 1.47(0.67–2.19) | 0.22405 | ||
| Not done | 981 (15.00) | 5629 (85.00) | 1.80 | 1.05(0.32–1.91) | 0.76982 | ||
| Negative | 275 (09.00) | 2845 (91.00) | 1.00 | ||||
| Aids | Yes | 135 (21.00) | 515 (79.00) | 1.67(1.36–2.04) | 0.00000 | 1.18(0.42–3.34) | 0.50850 |
| No | 1449 (14.00) | 9213 (86.00) | 1.00 | ||||
| Alcoholism | Yes | 196 (27.00) | 527 (73.00) | 2.56(2.13–3.07) | 0.00000 | 1.51(1.25–1.84) | 0.00003 |
| No | 901 (13.00) | 6197 (87.00) | 1.00 | ||||
| Diabetes | Yes | 42 (10.00) | 379 (90.00) | 0.69(0.49–0.96) | 0.02296 | 0.88(060–1.28) | 0.49742 |
| No | 1016 (14.00) | 6297 (86.00) | 1.00 | ||||
| Mental disorders | Yes | 24 (25.00) | 71 (75.00) | 2.17(1.32–3.59) | 0.00088 | 1.15(0.61–2.14) | 0.67120 |
| No | 1026 (13.00) | 6583 (87.00) | 1.00 | ||||
| Other comorbidities | Yes | 104 (20.00) | 422 (80.00) | 1.58(1.26–1.99) | 0.00005 | 1.31(1.01–1.71) | 0.04547 |
| No | 963 (13.00) | 6188 (87.00) | 1.00 | 1.00 | |||
| DOT | Yes | 287 (11.00) | 2380 (89.00) | 0.66(0.57–0.76) | 0.00000 | 0.72(0.55–0.94) | 0.01437 |
| No | 885 (16.00) | 4810 (84.00) | 1.00 | ||||
| Education level | ≤basic | 1248 (15.00) | 7019 (85.00) | 1.43(1.26–1.63) | 0.00000 | 1.35(1.15–1.57) | 0.00017 |
| >basic | 336 (11.00) | 2709 (89.00) | 1.00 | ||||
| Race | Black | 63 (16.00) | 339 (84.00) | 1.17 | 0.15334 | ||
| Yellow | 15 (18.00) | 69 (82.00) | 1.37 | ||||
| Mestizo | 1209 (14.00) | 7314 (86.00) | 1.04 | ||||
| Indigenous | 77 (11.00) | 625 (89.00) | 0.78 | ||||
| Ignored | 15 (16.00) | 78 (84.00) | 1.22 | ||||
| White | 200 (14.00) | 1264 (86.00) | 1.00 | ||||
| Age | Continuous variable | 37.32 | 36.45 | 0.71744 | 0.98(0.98–0.99) | 0.00160 | |
Treated living area: if the treatment was provided in the area where the patient lives. Living in Manaus: if the patient was living in the capital Manaus during treatment. Living area: the type of area where the patient lives: urban, periurban (near to urban areas but developing rural and urban activities), rural. Treatment type: the type of entrance of patient, if new case, if had received previous TB treatment but default, if was a relapse case or if transferred from another health unity. Clinical form: if TB case was pulmonary, extra pulmonary or mixed (pulmonary+extrapulmonary). AFB sputum smear: results of acid fast bacilli in sputum smear. HIV: results of serology or rapid test at moment of notification or during treatment. Aids: patients presenting Aids according WHO/MoH criteria at moment of notification. Alcoholism: condition recognized and declared by the patient at moment of notification. Diabetes (Diabetes mellitus): patient under treatment at moment of diagnosis, information registered in the patient file or declared by the patient. Mental disorders: condition declared at moment of diagnosis by patient's tutor or health professional or registered in the patient file. Other comorbidities: comorbidities not included in the standard questioner but declared by patients: heart disease, liver disease, kidney disease, neurological disease, cancer, mental disorders, and chemical dependency to illicit drugs. DOT: Directly Observed Treatment. Education level: ≤basic, comprehend illiterate and education up to 8 years of study; >basic: education above 8 years of study. Race: declared by patient at moment of notification. Age: Age of the patient at moment of diagnosis.