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. 2012 Jun 12;7(6):e38291. doi: 10.1371/journal.pone.0038291

Table 1. Amino acid sequences of the complementarity determining regions (CDRs) in 45 unique heavy chains of human Fab clones isolated from phage antibody library.

Fab clonesb CDR1 CDR2 CDR3
H2A12a SYSMN SISSSSSYIYYADSVKG EDYGL*****LDY
H2B10a ----- ----------------- -T---*****---
H2A1 ----- ----------------- -S--P*****---
H4G1 ----S -----R----------- -T---*****---
H2D3 ----- ----G------------ -S--P*****I--
H2F8a ----- ----GGN---------- -S--P*****---
H4D9 ----- ----R------------ -T--P*****---
H4B7 ----- ----G------------ -L--N*****---
H4A4a ----- ----G------------ DS-H-*****F--
H2B8a ----- ----G------------ DL--P*****---
H2C11a ----- ----G------------ DS--V*****-G-
H4C1 ----- ----G------------ DN--I*****F--
H2C2 ----- ----G------------ D---V*****S-V
H2C10a ----- ----R------------ DN--I*****F--
H4A6 T---- ----R------------ DN-A-*****M-V
H4E12 ----- ----N------------ DS--P*****--V
H4E5 ----- F---------------- DT--I*****F--
H4B2 ----- ----------------- D----*****I--
H2D7 ----S ----------------- D---V*****-H-
H2F10a ----- ----------------- D---S*****-SA
H2D12a ----- ----------------- DN--I*****F--
H4F7a ----- ----------------- DS---*****F--
H4G5 ----- ----------------- DN---*****F--
H2A8a ----- ----------------- DQ--V*****I--
H4E3 ----- ----------------- DL--V*****V-I
H4A7 ----- ----------------- -N--V*****I--
H2B4 ----- ----------------- -----*****M-V
H2B1a ----- ----------------- -N---*****M-V
H2A6 ----- ----------------- DS--I*****M-V
H2F5 ----- ----------------- DS--F*****M-V
H4G4 ----- ----------------- ----V*****-YV
H2A4a ----- ----------------- D---I*****S--
H4C9 ----- ----G------------ RN--E****YS--
H4B3 ----- ----G------------ TPG-IAVAEFM-V
H1C2a ----- ----------------- TPG-IAVAEFM-V
H2D1 T---- ----------------- TPG-IAVAEFM-V
H4C8a ----- ----------------- HFV-ASTH**T--
H2E4a ----- ----------------- GHV-ATD***---
H2F4a T---- ----------------- D---VIR***F-P
H4E11a -S--- ----GG----------- GGEYSSG***F--
H5D12 ----- ----G------------ LAA-ASSS**I--
H4B9a ----- ----G------------ TPG-GDYYY*M-V
H5A2 ----- ----------------- DL-YGDYV**---
H2H9a ----- ----------------- VT-YGSGSYFF--
H5D7 --W-H R-YTDG-STS------- GSSYYG****M-V
a

MAbs labeled were included in further study; b: MAbs derived from SFTS patients were designated as “H” for the first letter, and mouse derived MAbs were designated as “M” for the first letter; -: Indiated the identical to the amino acid sequence of Fab H2A12; *: No amid acid.