Table 1. Amino acid sequences of the complementarity determining regions (CDRs) in 45 unique heavy chains of human Fab clones isolated from phage antibody library.
Fab clonesb | CDR1 | CDR2 | CDR3 |
H2A12a | SYSMN | SISSSSSYIYYADSVKG | EDYGL*****LDY |
H2B10a | ----- | ----------------- | -T---*****--- |
H2A1 | ----- | ----------------- | -S--P*****--- |
H4G1 | ----S | -----R----------- | -T---*****--- |
H2D3 | ----- | ----G------------ | -S--P*****I-- |
H2F8a | ----- | ----GGN---------- | -S--P*****--- |
H4D9 | ----- | ----R------------ | -T--P*****--- |
H4B7 | ----- | ----G------------ | -L--N*****--- |
H4A4a | ----- | ----G------------ | DS-H-*****F-- |
H2B8a | ----- | ----G------------ | DL--P*****--- |
H2C11a | ----- | ----G------------ | DS--V*****-G- |
H4C1 | ----- | ----G------------ | DN--I*****F-- |
H2C2 | ----- | ----G------------ | D---V*****S-V |
H2C10a | ----- | ----R------------ | DN--I*****F-- |
H4A6 | T---- | ----R------------ | DN-A-*****M-V |
H4E12 | ----- | ----N------------ | DS--P*****--V |
H4E5 | ----- | F---------------- | DT--I*****F-- |
H4B2 | ----- | ----------------- | D----*****I-- |
H2D7 | ----S | ----------------- | D---V*****-H- |
H2F10a | ----- | ----------------- | D---S*****-SA |
H2D12a | ----- | ----------------- | DN--I*****F-- |
H4F7a | ----- | ----------------- | DS---*****F-- |
H4G5 | ----- | ----------------- | DN---*****F-- |
H2A8a | ----- | ----------------- | DQ--V*****I-- |
H4E3 | ----- | ----------------- | DL--V*****V-I |
H4A7 | ----- | ----------------- | -N--V*****I-- |
H2B4 | ----- | ----------------- | -----*****M-V |
H2B1a | ----- | ----------------- | -N---*****M-V |
H2A6 | ----- | ----------------- | DS--I*****M-V |
H2F5 | ----- | ----------------- | DS--F*****M-V |
H4G4 | ----- | ----------------- | ----V*****-YV |
H2A4a | ----- | ----------------- | D---I*****S-- |
H4C9 | ----- | ----G------------ | RN--E****YS-- |
H4B3 | ----- | ----G------------ | TPG-IAVAEFM-V |
H1C2a | ----- | ----------------- | TPG-IAVAEFM-V |
H2D1 | T---- | ----------------- | TPG-IAVAEFM-V |
H4C8a | ----- | ----------------- | HFV-ASTH**T-- |
H2E4a | ----- | ----------------- | GHV-ATD***--- |
H2F4a | T---- | ----------------- | D---VIR***F-P |
H4E11a | -S--- | ----GG----------- | GGEYSSG***F-- |
H5D12 | ----- | ----G------------ | LAA-ASSS**I-- |
H4B9a | ----- | ----G------------ | TPG-GDYYY*M-V |
H5A2 | ----- | ----------------- | DL-YGDYV**--- |
H2H9a | ----- | ----------------- | VT-YGSGSYFF-- |
H5D7 | --W-H | R-YTDG-STS------- | GSSYYG****M-V |
MAbs labeled were included in further study; b: MAbs derived from SFTS patients were designated as “H” for the first letter, and mouse derived MAbs were designated as “M” for the first letter; -: Indiated the identical to the amino acid sequence of Fab H2A12; *: No amid acid.