Figure 4. Induction of SIV-specific IFN-γ secreting cells by control but not by DEC-205 targeting DNA.

At weeks 10, 13, and 16, PBMCs were stimulated for 17–20 h with either AT2-inactivated SIV (A) or a Gag-specific peptide pool (B), and numbers of IFN-γ producing cells were determined in ELISPOT assays. Numbers of spots per 10⁶ cells are presented for each animal and each point in time (line, median; #, p<0.05 compared with C and D, †, p<0.05 compared with A; one-way ANOVA followed by Bonferroni Post test).