Table 2. Logistic regression models to predict antimony treatment failure of ulcerative cutaneous leishmaniasis.

Factor	Univariate analysisa OR (95% CI)	P-value	Multiple-variable analysis 1b OR (95% CI)	P-value	Multiple-variable analysis 2c OR (95% CI)	P-value
Age	0.94 (0.89–0.97)	0.003	0.88 (0.81–0.97)	0.010	0.92 (0.88–0.98)	0.008
Duration of disease	0.99 (0.97–1.00)	0.138	0.97 (0.95–0.99)	0.025	0.97(0.94–0.99)	0.02
high-risk/low risk Activity	0.098 (0.02–0.46)	0.003	0.07 (0.009–0.54)	0.011	0.12(0.02–0.75)	0.02
Number of lesion(s)	0.93 (0.32–2.7)	0.896
Total area of lesion(s)*	0.499 (0.31–0.82)	0.006	0.53 (0.27–1.04)	0.065
Concomitant-distant lesion(s)
No	1		1		1
Yes	4.92 (1.24–19.48)	0.023	30.5 (1.67–558.56)	0.021	6.27(0.96–40.7)	0.054
Leishmania species
L guyanensis	1		1
L braziliensis	5.17 (0.97–27.60)	0.054	25.7 (2.34–282.30)**	0.008
L peruviana	2.93 (0.56–15.19)	0.200	1

^aOdds ratio and its 95% confidence interval of the simple logistic regression in the univariate analysis.

^bOdds ratio and its 95% confidence interval of the multiple logistic regression for the Prognostic Score 1. R² = 0.54; 85 patients in the model.

^cOdds ratio and its 95% confidence interval of the multiple logistic regression for the Prognostic Score 2 (without inclusion of the Leishmania species). R² = 0.38; 85 patients in the model.

*: This variable was log-transformed before the analysis.

**: Odds ratio obtained after pooling L. guyanensis and L. peruviana and comparing against L. brasiliensis.