Figure 2. GW788388 administration at 3 dpi decreased liver and renal alterations.

Male Swiss mice were injected IP with or without (NI) 10⁴ bloodstream trypomastigotes. Then GW788388 (3 mg/kg) or DMSO was administered by gavage at 3 dpi. (A and B) At 15 dpi mice were sacrificed, and liver sections stained with hematoxylin-eosin were analyzed by light microscopy. Large inflammatory infiltrates (A, white arrow) were observed in untreated T. cruzi-infected mice. (C) The mean number of inflammatory infiltrates (more than 10 mononuclear cells) in 30 fields is shown. (D and E) The serum levels of AST and ALT, two markers of hepatic lesion, were measured at 15 dpi. (F) The serum urea levels were measured to evaluate renal function. Each symbol shows the value for one mouse. The short black bars show the mean value for each group. Values that were significantly different from studied groups are indicated by asterisks (**p<0.01 and * p<0.05). n = 3 mice/group in 3 independent experiments.