Table 2. Effect of GW788388 on electrocardiograph parameters at 15 dpi.
| ECG parameters (Mean ± SD) | Non-infected | Y + DMSO | Y + GW788388 |
| Heart rate (bpm) | 774.2±30.6 | 495.8±79.2a | 554.3±44.5c |
| PR intervals (ms) | 28.6±3.1 | 50.4±8.2a | 45.1±8.4 |
| QRS intervals (ms) | 8.6±1.4 | 10.6±2.7b | 9.7±2.0 |
| QT intervals (ms) | 22.8±8.9 | 29.6±5.5b | 25.3±6.4c |
| Frequency of AVB1 | 0/10 (0%) | 15/18 (83%) | 5/18 (28%) |
| Frequency of AVB2 | 0/10 (0%) | 13/18 (72%) | 6/18 (33%) |
ECG parameters were evaluated in the acute phase at 15 dpi, using the following standard criteria: (i) the heart rate was monitored by beats/minute (bpm), and (ii) the variation at P wave and PR, QRS and QT intervals, all measured in milliseconds (ms). The incidence of AVB1, atrioventricular block type 1 and AVB2, atrioventricular block type 2 are stated in absolute numbers and in percentage. Significant differences between the values for non-infected and infected groups of mice:
a
(p<0.01) and.
b
(p<0.05).
c
Significant differences (p<0.05) between the values for infected non treated (Y DMSO) and treated (Y GW788388) groups of mice.