Table 4. Effect of GW788388 on the fibrosis scores of the heart at 20 dpi.

	dpi 15 DMSO	dpi 20 DMSO	dpi 24 DMSO	dpi 24 GW788388
Number of mice	7	8	10	6
% area stained for Masson' Trichrome	25.7	33.8	55.8	4.8
	23.9	18.8	35.7	6.2
	22.6	14.4	30.0	3.1
	5.2	53.8	7.7	2.9
	56.1	55.9	8.2	2.9
	5.1	13.2	13.7	8.3
	nd	39.4	54.0
		16.1	54.0
			20.2
			9.2
Mean ± SD	23.1±18.6	30.7±17.6	28.9±20.0	4.7±2.2**

T. cruzi infected mice were treated with 3 mg/kg GW788388 at 20 dpi and fibrosis was quantified before (15 and 20 dpi) and after (24 dpi) treatment. Percent of Masson's Trichrome stained area (light blue areas) were quantified using NIH ImageJ Software in the microscopic images of heart sections.

**: Significant differences (p<0.01) between the values for Y DMSO and Y GW788388 groups of mice observed at 24 dpi. nd: not detected.