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. Author manuscript; available in PMC: 2012 Jun 12.
Published in final edited form as: Nature. 2011 Sep 14;477(7364):335–339. doi: 10.1038/nature10400

Figure 1. Casp8ΔIEC mice spontaneously develop ileitis and lack Paneth cells.

Figure 1

(a) Representative endoscopic pictures and (b) H&E stained cross sections showing villous erosions in the terminal ileum of Casp8ΔIEC. (c) RT-PCR showing increased level of inflammatory markers in the terminal ileum of Casp8ΔIEC mice (6 mice per group +SEM, relative to HPRT). (d) Gene ontology analysis of genes significantly downregulated in gene chip analysis of IEC from 3 control and 3 Casp8ΔIEC mice. (e) Ileum cross sections stained with H&E and lysozyme for Paneth cells (inset = single crypt at higher magnification). Arrows indicate crypt bottom with Paneth cells.