Table 3.

Enantioselective Alkylation: Carboxylic Acid Scope^a

1	2	3	4	5	6	7	8
96% ee 84% yield	96% ee 81% yield	93% ee 65% yield	89% ee 71% yield	96% ee 83% yield	93% ee 82% yield	94% ee 82% yield	93% ee 87% yield
9	10	11	12	13	14	15	16
92% ee 82% yield	92% ee 89% yield	96% ee 88% yield	97% ee 60% yield	92% ee 62% yield	90% ee 85% yield	0% ee 12% yield	95% ee 61% yieldb
17	18	19	20	21	22	23	24
84% ee 71% yield	X=H, 91% ee, 87% X=F, 85% ee, 73%	92% ee 87% yield	88% ee 87% yield	94% ee 96% yield	97% ee 78% yield	91% ee 70% yield	96% ee 89% yield

^aEnantiomeric excess was determined by HPLC using a chiral stationary phase (see the Supporting Information for details).

^bIsolated yield of the corresponding alcohol over two steps after reduction of the acid with LiAlH₄.