Table 2.
Neuroproteomic studies related to psychiatric disease and drug addiction.
| Tissue Source (#samples) | Tissue | Technique | # Altered Proteins | Protein categories | Secondary Analysis | Ref # |
|---|---|---|---|---|---|---|
| Human - suicide victims (17) and controls (9) | Prefrontal cortex | 2-DE | 3 | Protein folding, glial activity, oxidative stress | No | [74] |
| Human - schizophrenic (15), bipolar (15), major depressive (15) patients and controls (15) | Anterior cingulate cortex | 2-DE | 26 | Energy metabolism, synaptic plasticity | Immunoblott (3) | [69] |
| Human – schizophrenic patients (10) and controls (10) | Anterior cingulate cortex | 2-DE | 39 | Energy metabolism, synaptic plasticity | No | [70] |
| Rat - Clozapine-treated(12), chlorpromazine-treated (14), and control (12) | Hippocampus | 2-DE | 4 | Energy metabolism, oxidative stress, signaling | No | [72] |
| Mouse - Bred for high (8) versus low (8) anxiety-related behavior | Hypothalamus, amygdala, and motor cortex | 2-DE | 1, 1, 1 | Energy metabolism | Microarray and Immunoblott (1) | [79] |
| Rat - With voluntary exercise (5) and sedentary animals (5) | Hippocampus | 2-DE | 80 | Energy metabolism, synaptic plasticity | Immunoblott (2) | [80] |
| Mouse - Chronic corticosterone treament (8) and control (8) | Hypothalamus, hippocampus, and cerebral cortex | DIGE | 25, 33, 22 | Energy metabolism, synaptic plasticity, cell death | Immunoblott (4) | [75] |
| Human - Complicated (6), uncomplicated alcoholics (8) and controls (10) | dorsolateral prefrontal cortex | 2-DE | 18 | Energy metabolism, synaptic plasticity | No | [83] |
| Rat - Nicotine treated (10) and control (10) | Striatum | 2-DE | 7 | Cell death, signaling | RT-PCR (3) | [86] |
| Rat - Nicotine treated (6) and control (6) | Amygdala, N. accumbens, prefrontal cortex, striatum, VTA | 2-DE | 14, 11, 19, 13, 19 | Energy metabolism, synaptic function, oxidative stress | No | [87] |
| Rat - Sucrose self-administration (6) and control (5) | Medial prefrontal cortex | 2-DE | 28 | Synaptic plasticity, energy metabolism, synaptic function | RTqPCR (5) | [101] |
| Rat - Chronic morphine exposure (3) and control (3) | Forebrain synaptosomes | ICAT | 27 | Synaptic plasticity, energy metabolism, synaptic function | No | [89] |
| Mouse - Morphine exposure (5 pooled) and control (5 pooled) | Hippocampal PSDs | ICAT | 23 | Signaling, synaptic function | Immunoblot (5) EM (1) |
[90] |
| Rat - Chronic morphine exposure (5) and control (5) | Nucleus accumbens | 2-DE | 15 | Energy metabolism, synaptic function, synaptic plasticity | No | [93] |
| Rat - Morphine exposure (3) and control (3) | Frontal cortex | 2-DE + pTyr blotting | 46 | Energy metabolism, synaptic plasticity, signaling | No | [95] |
| Rat - Amphetamine self-administration: abstinent (3) versus binge (3), relapse (3), and control (3) | Hippocampus | DIGE | 22 | Synaptic plasticity, oxidative stress, energy metabolism | No | [96] |
| Mouse - Methamphetamine exposure (12) and control (12) | Striatum | 2-DE | 5 | Synaptic function, synaptic plasticity, oxidative stresss | Immunoblot (2) | [98] |
| Rat - Exposed to repeated social defeat (6) and control (6), single social defeat (5) and control (5) | Hippocampus | 2-DE | 21, 8 | Energy metabolism, synaptic plasticity, protein folding | No | [76] |