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. Author manuscript; available in PMC: 2013 Jun 1.
Published in final edited form as: Dev Comp Immunol. 2012 Apr 12;37(2):306–312. doi: 10.1016/j.dci.2012.04.003

Figure 5. Model of Jagged-Notch interactions and M cell patterns in Peyer’s patch epithelium.

Figure 5

A. A low magnification view of the overall distribution of M cells (green) across Peyer’s patch follicle epithelium. Note that at this low magnification, dispersion of M cells derived from crypt stem cell progenitors is evident, though the rare M cell clusters are not as visible.

B. Simplified cartoon model of M cell editing by Jagged1 and Notch interactions, indicating a possible role for Jagged1 in both lateral inhibition of M cell development and cis-reinforcement of M cell lineage decisions.