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. Author manuscript; available in PMC: 2013 Jun 1.
Published in final edited form as: Mol Cancer Ther. 2012 Apr 5;11(6):1320–1331. doi: 10.1158/1535-7163.MCT-11-0954

Figure 6.

Figure 6

Combination of Rad001 and Propachlor significantly inhibits the PC3 xenograft tumors in mice. (A) Anti-tumor activity on PC3 xenografts by various compounds. Mice were administered daily i.p. with Rad001 (1 mg/kg), Propachlor (5 mg/kg) or both (6 mice/group). The tumor sizes (left) and body weights (right) were measured every four days. Tumors treated with two drugs were much smaller than single compound treatment or control. (B) Electron microscopic analysis of the tumors collected from various treatment groups. Arrows indicate autophagosomes. (C) Quantitation of the number of autophagosomes in 30 cells from the xenograft tumors. (D) Immunoblot analysis for LC3 and Beclin 1 from the xenograft tumors.