NTERA-2 cells, which continually express OCT4, were treated for 16 hours with the indicated doses of doxorubicin, then examined for expression of mir-145 and OCT4 mRNA by qPCR. Expression levels were normalized to untreated NTERA-2 cells, which were arbitrarily set at 1.0. Note, with increasing doses of doxorubicin, mir-145 expression levels increase with a concomitant decrease in OCT4 expression levels. n = 3 for each group.