Table 3.
Gene | Name | SNP | Protein Change | Nucleotide Change | P value† <1 mo | P value < 6 mo | P value <1 yr |
---|---|---|---|---|---|---|---|
ACE | Angiotensin I-converting enzyme | rs4340 | Intron | In/del | 0.0689 | 0.4978 | 0.5365 |
AGT | Angiotensinogen | rs4762 | p.207T/M | c.620C/T | 0.5664 | 0.3909 | 0.3052 |
AGT | Angiotensinogen | rs699 | p.268M/T | c.803T/C | 0.1162 | 0.0627 | 0.1475 |
CCR5 | chemokine (C-C motif) receptor 5 | rs333 | Truncating mutation | c.554_585del32 | 0.8392 | 0.0791 | 0.1747 |
F2 | Prothrombin | rs1799963 | None | c.20269G/A | 0.2255 | 0.1897 | 0.4328 |
F5 | Coagulation Factor V | rs6025 | p.534R/Q | c.1602G/A | 0.5046 | 0.6043 | 0.4886 |
GNB3 | G protein B3 Subunit | rs5443 | p.275S/S | c.825C/T | 0.0670 | 0.2494 | 0.1230 |
ICAM1 | Intercellular adhesion molecule-1 | rs1799969 | p.241G/R | c.721G/A | 0.2406 | 0.4366 | 0.6852 |
ICAM1 | Intercellular adhesion molecule-1 | rs5498 | p.469K/E | c.1405A/G | 0.5013 | 0.4271 | 0.4554 |
IFNG | Interferon-γ | rs2430561 | Intron | c.114+760T/A | 0.6270 | 0.2999 | 0.6950 |
IL2 | Interleukin-2 | rs2069762 | Promoter | c.-385T/G | 0.6240 | 0.7336 | 0.7225 |
IL6 | Interleukin-6 | rs1800795 | Promoter | c.-237C/G | 0.9769 | 1.000 | 0.9882 |
IL10 | Interleukin-10 | rs1800896 | Promoter | c.-1117C/T | 0.2996 | 0.5147 | 0.4032 |
IL10 | Interleukin-10 | rs1800871 | Promoter | c.-854A/G | 0.5953 | 0.2026 | 0.4729 |
IL10 | Interleukin-10 | rs1800872 | Promoter | c.-627G/T | 0.8110 | 0.2101 | 0.4185 |
ITGB3 | Platelet Glycoprotein IIIA | rs5918 | p.59L/P | c.176T/C | 0.4851 | 0.4678 | 0.4683 |
MTHFR | Methylenetetrahydrofolate | rs1801133 | p.222A/V | c.665C/T | 0.0733 | 0.0356 | 0.0908 |
MTHFR | Methylenetetrahydrofolate | rs1801131 | p.429E/A | c.1286/C | 0.4388 | 0.3943 | 0.2826 |
TGFB1 | Transforming Growth Factor-β1 | rs1800470 | p.10P/L | c.29C/T | ND | ND | ND |
TNF | Tumor Necrosis Factor-α | rs1800629 | Promoter | c.-488A/G | 0.3896 | 0.2194 | 0.5421 |
TNF | Tumor Necrosis Factor-α | rs361525 | Promoter | c.-418A/G | 0.1324 | 0.3035 | 0.4369 |
p value for AR within the specific time post-transplant