. Author manuscript; available in PMC: 2013 Aug 1.

Published in final edited form as: Pediatr Blood Cancer. 2012 Apr 19;59(2):365–371. doi: 10.1002/pbc.24178

Table II.

Toxicity Results in Recent Studies of Hydroxyurea for Sickle Cell Disease

Study, Year	Drug	ANC 500–1250/ul	ANC <500/ul	Platelets <80,000/ul	Rash/nail changes	Sepsis or bacteremia	Other
BABY HUG 2011 (9)	HU	107 events in 45participants ↓ dose in 9 P<0.00001	5 in 5 P=0.26	12 in 11 P=0.32	122 in 62 P=0.08	3 in 2 P=0.26	Reticulocytopenia, chromosome and chromatid breaks, VDJ recombination events, and micronuclei assay results were similar in both groups
BABY HUG 2011 (9)	Placebo	34 events in 18 participants ↓ dose in 5	2 in 2	8 in 7	165 in 69	6 in 5
CHAMPS 2011(10)	HU	1	0	0	NR	NR	No difference in diarrhea and abdominal pain among groups
CHAMPS 2011(10)	Placebo	1	0	0	NR	NR	No difference in diarrhea and abdominal pain among groups

HU indicates hydroxyurea; ANC, absolute neutrophil count.