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. Author manuscript; available in PMC: 2013 Aug 1.
Published in final edited form as: Xenobiotica. 2012 Mar 8;42(8):748–755. doi: 10.3109/00498254.2012.662726

Figure 3. Expression and localization of BCRP in human brain tumor biopsy specimens.

Figure 3

(A) Immunohistochemical analysis of BCRP in healthy, control human brain biopsy. BCRP staining of brain endothelial cells (denoted as *) and significant cytoplasmic/membraneous expression without nuclear expression of BCRP in brain glial cells; (B) A strong BCRP signal was observed in the cytoplasmic/membraneous compartment of a human breast cancer specimen. No nuclear BCRP staining was noted; (C) Biopsy GBM specimen at low (200X) and high (400X) magnification (inset) demonstrating nuclear BCRP staining in a subpopulation of tumor cells (denoted by arrows).