Figure 3. Effect of L-4F treatment in chow diet on tumor number and size in the intestinal tract of C57BL/6J-Apc^Min/+ mice.

Apc^Min/+ mice were sacrificed after 8 weeks treatment with sc-4F or L-4F administered in mouse chow as described under Materials and Methods. (A) Total tumor numbers in the intestinal tract after treatment with L-4F administered in mouse chow for 8 weeks represented as a percent of the control (i.e. mice treated with sc-4F), P < 0.05. (B) Numbers of tumors in different size categories defined by the diameter of the tumor in mm. w/sc-4F, mice treated with sc-4F; w/L-4F, mice treated with L-4F. (C) Plasma LPA levels are significantly decreased (> 50%) in C57BL/6J-Apc^Min/+ mice treated with L-4F compared to control mice. P < 0.01.