Figure 1.

miRNA families. The sequences of the five members of the miR-8 family are shown; the shared seed sequences are shown in red. An mRNA with RISC bound to three different loci in its 3′-UTR is shown; the net effect of these interactions can be diminished translation or mRNA degradation. m⁷G, 7-methylguanosine in the 5′-cap; orange ball, cap-binding complex; ORF, open reading frame; AAAAA, poly A tail. Mismatches are shown as loops.