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. 2012 Jun 13;3:55. doi: 10.3389/fpsyt.2012.00055

Figure 1.

Figure 1

The position of the methylation probes relative to the structure of SLC6A4. Numbers in bold represents the 14 exons present in this gene. Dark blue ovals correspond to untranslated regions (UTR) of SLC6A4 while light blue ovals correspond to translated portions of the exons with the translation start site being contained within exon 2. The “first exon” actually contains three variably splice DNA segments labeled 1A, 1C, and 1B. The identity of the methylation probes is indicated by boxes with Roman numerals. Probes I (cg1207449), II (cg06841846), and III (cg18584905) are situated at the “south shore” of the gene upstream of the transcription start site (TSS). Probes IV (cg27569822), V (cg10901968), VI (cg26741280), VII (cg25725890), and VIII (cg05016953) are contained within the portion of the CpG island proper upstream of the transcription start site (TSS) while Probe IX (cg14692377) is contained both within the CpG island proper and exon 1A. Probes X (cg03363743), XI (cg22584138), and XII (cg05951817) are situated at the north shore and Probe XIII (cg26126367) at the north shelf of the gene in intron 1A. Probe XIV (cg01330016) is in intron 1B while Probe XV (cg24984698) intron 2. Finally, Probe XVI (cg20592995) is immediately distal to the 3′UTR. The transcription start site is at exon 1A.