Table 3.
Single nucleotide polymorphisms associated with omphalocele based on logistic regression analyses stratified by race/ethnicity.
| Race/Ethnicity | Gene | SNP | Description | Allelesa | Control Genotypesb | Case Genotypesb | Adjusted odds ratio (95% Confidence Interval)c | |
|---|---|---|---|---|---|---|---|---|
| Heterozygous | Homozygous for minor allele | |||||||
| African-American | MTHFR | rs1801131 | c.1298A>C | A/C | 148/44/2 | 32/12/3 | 1.34 (0.63, 2.83) | 6.44 (1.03, 40.41) |
| BHMT | rs3733890 | p.R239Q | G/A | 138/52/5 | 23/18/4 | 2.05 (1.02, 4.12) | 4.62 (1.15, 18.52) | |
| TCblR | rs173665 | C>T (3′ near gene) | G/A | 142/52/1 | 31/11/3 | 0.98 (0.46, 2.10) | 13.27 (1.33, 132.35) | |
| TCblR | rs2232775 | p.Q8R | A/G | 69/94/32 | 12/18/15 | 1.09 (0.49, 2.42) | 2.74 (1.14, 6.57) | |
| TCN2 | rs9606756 | p.I23V | A/G | 146/40/9 | 24/20/2 | 2.92 (1.46, 5.83) | 1.40 (0.28, 6.90) | |
| TCN2 | rs9621049 | p.S348F | C/T | 147/42/6 | 26/18/1 | 2.38 (1.19, 4.77) | 0.96 (0.11, 8.30) | |
| Asian | MTHFR | rs1801131 | c.1298A>C | A/C | 20/13/3 | 1/6/1 | 13.54 (1.22, 150.88) | 4.62 (0.20, 106.66) |
| BHMT | rs3733890 | p.R239Q | G/A | 21/13/2 | 1/6/1 | 14.30 (1.34, 152.78) | 18.25 (0.56, 591.86) | |
a
Major allele is listed first
b
Genotype values are numbers of individuals in the race/ethnic group with homozygous major allele/heterozygous/homozygous minor allele
c
Homozygous for major allele was reference category; adjustment for maternal education and in vitro fertilization/assisted reproductive technique