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. Author manuscript; available in PMC: 2012 Jun 13.
Published in final edited form as: Trends Biochem Sci. 1996 Sep;21(9):351–355.

Figure 2.

Figure 2

Model for regulation of Elongin (SIII) transcriptional activity by the von Hippel–Lindau (VHL) tumor suppressor protein. (a) The Elongin BC complex binds to Elongin A and induces its transcriptional activity. The fully assembled Elongin ABC complex strongly stimulates the overall rate of elongation by RNA polymerase II. (b) The VHL tumor suppressor protein can bind to the Elongin BC complex. Binding of the VHL protein and Elongin A to the Elongin BC complex is mutually exclusive. In addition, binding of the VHL protein to the Elongin BC complex prevents Elongin BC from interacting with Elongin A. One role of the VHL tumor suppressor protein, therefore, might be to regulate the activity of the RNA polymerase II (Pol II) elongation complex. Other abbreviations used: A, Elongin A; B, Elongin B; C, Elongin C; V, VHL.