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. Author manuscript; available in PMC: 2013 May 12.
Published in final edited form as: Eur J Pharm Sci. 2012 Feb 8;46(1-2):8–16. doi: 10.1016/j.ejps.2012.01.012

Table 4.

Pharmacokinetic parameters for DIM-P in rats following simultaneous three compartment model fit for i.v. and oral administration.

Parameter Estimate CV%
Disposition CLC (mL min−1 kg−1) 0.77 13.81
CLd1 (mL min−1 kg−1) 0.606 13.04
CLd2 (mL min−1 kg−1) 0.319 24.86
VC (mL kg−1) 13.9 16.04
V1 (mL kg−1) 646.06 42.43
V2 (mL kg−1) 28.50 47.17
Absorption FBIO 0.126 7.93
Tsite (min) 85.20 18.22
Abmax (μg min−1 kg−1) 60.65 37.15
SD50 (μg kg−1) 8679.7 55.76